TRβ infection–induced p21 expression and Go/G1 growth arrest.

<p>(A–C) Western blot analysis of the expression level of p21 or of the phosphorylated Rb protein in AdTRβ-infected BHP18-21v (A), FRO (B), or WRO (C) cells that were exposed to 30 nM of T3 alone for 12 h or to 30 nM T3 plus 5 µM of FTI for 12 h, with or without siRNA knockdown of RhoB as indicated. Tubulin was blotted as a loading control (bottom panels). (D–F) The percentage of cells in the G₀/G₁, S, or G₂/M phase was calculated by using ModFitLT version 3.1. Data are expressed as means ± S.D. (<i>n</i> = 6). *, <i>p</i><0.05.