Wildtype mice show no alterations in exploratory activity or anxiety-like behavior after 2-hit injury.

<p>Wildtype mice (n = 8–10 per group) received a 2-hit frontal impact injury or sham treatment, followed by assessment in different behavioral tests. (A–D) Open field activity 2 weeks post-injury. (E–H) Behavior in elevated plus maze 4 weeks post-injury. Student's t test revealed no significant differences between the 2-hit and sham treated groups for any of the tests and outcome measures. Data are means ± SEM.