The motor performance was estimated using a negative geotactic assay.

<p>The HD models (A, B) and the SCA1 models (C, D) were tested at 7 days (A, C) and 14 days (B, D). Each Gal4 driver tested is listed along the X-axis. “-” on the X-axis corresponds to “no driver” controls. The Y-axis represents the time to reach 5 cm (seconds). Each bar represents the mean ± SE. Single or double asterisks indicate significant differences (p<0.05 or p<0.01, respectively). The numbers of flies tested in each experiment (between 7 and 20) are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116567#pone.0116567.s005" target="_blank">S1 Table</a>. For each of the disease models that expressed Htt-103Q or ATXN1-82Q we tested about 20 flies. Because the short Q controls showed stable performance we only about 8 flies for each group. The results of the statistical analyses are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116567#pone.0116567.s008" target="_blank">S4 Table</a>.