Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from <i>o</i>‑Iodoanilines, Isocyanide, and Potassium Sulfide

An efficient copper catalyzed strategy for the synthesis of a variety of benzothiazolethione derivatives has been developed. In the presence of CuCl, the three-component reaction of <i>o</i>-iodoanilines and K₂S with <i>p</i>-toluenesulfonylmethyl isocyanide proceeded smoothly to obtain the corresponding benzothiazolethiones in good to excellent isolated yields. Notably, isocyanide functioned as a carbon source and K₂S functioned as a sulfur source in this reaction