Aptamers are promising recognition elements for sensitive and specific detection of small molecules. We have previously selected ssDNA aptamers for ethanolamine, one of the smallest aptamer targets so far. The work presented here focuses on the determination of the binding region within the aptamer structure and its exploitation for the development of an aptamer-based assay for detection of ethanolamine. Sequence analysis of the aptamers resulted in the identification of a G-rich consensus sequence, which was able to fold in a typical two- or three-layered G-quartet structure. Experiments with stepwise truncated variants of the aptamers revealed that the consensus sequence is responsible and sufficient for binding to the target. On the basi...
Although much effort has been made for studies on aptamer–target interactions due to promising appli...
Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable...
honors thesisCollege of ScienceChemistryJennifer HeemstraPrescription drug overdose and abuse is a l...
WOS:000489191200004A label free aptasensor based on G-quadruplex forming ethanolamine aptamers and T...
Aptamers are short oligonucleotide sequences (DNA or RNA) capable of high affinity and specific bind...
Aptamers have recently gained considerable attention for small-molecule detection in diverse applica...
Aptamers are synthetic single-stranded DNA or RNA sequences that can fold into tertiary structures a...
La détection de petites molécules est d'un grand intérêt dans les domaines pharmaceutique, environne...
Aptamers are functional nucleic acid (FNA) species capable of specifically binding a target ligand w...
There is a great need for fast, simple and precise diagnostic assays capable of direct quantificatio...
DNA sequences that can bind selectively and specifically to target molecules are known as aptamers. ...
WOS: 000312119500003Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are ab...
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabili...
Nucleic acid aptamers are versatile molecular recognition agents that bind to their targets with hig...
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabili...
Although much effort has been made for studies on aptamer–target interactions due to promising appli...
Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable...
honors thesisCollege of ScienceChemistryJennifer HeemstraPrescription drug overdose and abuse is a l...
WOS:000489191200004A label free aptasensor based on G-quadruplex forming ethanolamine aptamers and T...
Aptamers are short oligonucleotide sequences (DNA or RNA) capable of high affinity and specific bind...
Aptamers have recently gained considerable attention for small-molecule detection in diverse applica...
Aptamers are synthetic single-stranded DNA or RNA sequences that can fold into tertiary structures a...
La détection de petites molécules est d'un grand intérêt dans les domaines pharmaceutique, environne...
Aptamers are functional nucleic acid (FNA) species capable of specifically binding a target ligand w...
There is a great need for fast, simple and precise diagnostic assays capable of direct quantificatio...
DNA sequences that can bind selectively and specifically to target molecules are known as aptamers. ...
WOS: 000312119500003Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are ab...
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabili...
Nucleic acid aptamers are versatile molecular recognition agents that bind to their targets with hig...
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabili...
Although much effort has been made for studies on aptamer–target interactions due to promising appli...
Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable...
honors thesisCollege of ScienceChemistryJennifer HeemstraPrescription drug overdose and abuse is a l...