Stimulation geometry strongly influences signal and noise correlations in ELL pyramidal cells.

<p><b>A</b>) For local stimulation geometry, the stimulus is delivered via a small dipole located close to the animal's skin. <b>B</b>) For global stimulation, the stimulus is instead delivered via two electrodes located 15 cm away from the animal on each side. <b>C</b>) Population-averaged cross-correlograms (CCGs) from same type pyramidal cell pairs recorded from simultaneously for global (blue) and local (red) 4 Hz sinusoidal stimulation. <b>D</b>) Population-averaged noise CCGs from same type pyramidal cell pairs recorded from simultaneously for global (blue) and local (red) 4 Hz sinusoidal stimulation. <b>E</b>) CCGs from our model under simulated global (blue) and local (red) 4 Hz sinusoidal stimulation. <b>F</b>) Noise CCGs from our model under simulated global (blue) and local (red) 4 Hz sinusoidal stimulation. <b>G</b>) Population-averaged cross-correlation coefficient R for global (blue) and local (red) 4 Hz sinusoidal stimulation. <b>H</b>) Population-averaged cross-correlation coefficient R for our model under simulated global (blue) and local (red) 4 Hz sinusoidal stimulation. “*” indicates statistical significance at the p = 0.05 level using a signrank test with N = 18.