Functional activity profiles of <i>T. cruzi</i>-specific CD8⁺ T cell subsets from CCPs with different degrees of disease severity.

<p>(<b>A</b>) Frequencies of CD8⁺ T_SCM, T_CM, T_EM and T_TE cells with one, two and three functions among CD8⁺ T cells stimulated with Staphylococcal enterotoxin B (SEB). (<b>B</b>) Frequencies of CD8⁺ T_SCM, T_CM, T_EM and T_TE cells with one, two and three functions among CD8⁺ T cells stimulated with parasite lysate. Box and whiskers indicate the median frequency and range of the CD8⁺ T cell subsets (25–75 percentile). CCPs were grouped according to their disease severity as described in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003432#s2" target="_blank">Materials and Methods</a> (A = 8, B = 6, C = 6 and D = 4). Additionally, nine HDs were included.