<p>(A) Infectivities of JR-FL wt and indicated point mutant envs were determined by titration of virus stocks on TZM-bl reporter cells and are shown normalized to JR-FL wt. Data depict mean and SD from 4 independent experiments. (B) Relative infectivity of mixed trimer infection experiments with the specified JR-FL variants using the R508S/R511S and V513E dominant-negative mutations are shown. Infectivity of pseudotyped virus stocks expressing the indicated ratios of dominant-negative mutant envs was measured on TZM-bl cells. Infectivity of virus stocks containing solely functional envelope were set as 100%. Data depict mean and SD from 2 independent experiments. (C) Mathematical analyses of the data shown in (B) yielded estimates of T, sho...
<p>A) Net growth rates of individual <i>gag</i> viruses in competitions. B) Net growth rate differen...
<p>(A) Relative fitness of 3D<sup>G64S</sup> as measured by direct competition. The amount of each v...
<p>Wild-type MEF cells (A) and IRF3/7 knockout MEF cells (B) were infected by Romero (Rom) and Candi...
<p>(A) Schematic representation of JRFL WT and four different SP mutations evaluated in this study. ...
<p>(A) Comparison of infectivity of pseudoviruses expressing wt and V1V2-deleted envs upon infection...
<p>(A) Theoretical predictions of relative virus infectivity over the fraction of dominant-negative ...
<p>(A) Titration of CAP88 wt (black) and CAP88 K160N (red) pseudoviruses on TZM-bl reporter cells. D...
<p>(A) Scheme depicting the influence of the entry stoichiometry on virus population infectivity. Di...
<p>(A) Entry kinetic curves for JR-FL wt and JR-FL ΔV1V2. Synchronized pseudovirus infection of TZM-...
<p>(A) HeLa cells, treated with 200 µM or 400 µM ribavirin, or left untreated, were infected at an M...
<p>Cell lines (293T, HeLa, NP2 and GHOST) were transfected with equal amount of wild-type pNL-AD8 (W...
<p>(A) Infectivity was assayed using equal titers of 10-day wild-type (WT), C428S, C175S, C185S, C17...
<p>(a) Blue stained TZM-bl cells that had been infected by RRR, RKR and KKK mutants of viruses NL-95...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
(A). The amino-acid sequence of the 6K region from WT SINV, Δ6K SINV, p7 SINV, M2 SINV, and Vpu SINV...
<p>A) Net growth rates of individual <i>gag</i> viruses in competitions. B) Net growth rate differen...
<p>(A) Relative fitness of 3D<sup>G64S</sup> as measured by direct competition. The amount of each v...
<p>Wild-type MEF cells (A) and IRF3/7 knockout MEF cells (B) were infected by Romero (Rom) and Candi...
<p>(A) Schematic representation of JRFL WT and four different SP mutations evaluated in this study. ...
<p>(A) Comparison of infectivity of pseudoviruses expressing wt and V1V2-deleted envs upon infection...
<p>(A) Theoretical predictions of relative virus infectivity over the fraction of dominant-negative ...
<p>(A) Titration of CAP88 wt (black) and CAP88 K160N (red) pseudoviruses on TZM-bl reporter cells. D...
<p>(A) Scheme depicting the influence of the entry stoichiometry on virus population infectivity. Di...
<p>(A) Entry kinetic curves for JR-FL wt and JR-FL ΔV1V2. Synchronized pseudovirus infection of TZM-...
<p>(A) HeLa cells, treated with 200 µM or 400 µM ribavirin, or left untreated, were infected at an M...
<p>Cell lines (293T, HeLa, NP2 and GHOST) were transfected with equal amount of wild-type pNL-AD8 (W...
<p>(A) Infectivity was assayed using equal titers of 10-day wild-type (WT), C428S, C175S, C185S, C17...
<p>(a) Blue stained TZM-bl cells that had been infected by RRR, RKR and KKK mutants of viruses NL-95...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
(A). The amino-acid sequence of the 6K region from WT SINV, Δ6K SINV, p7 SINV, M2 SINV, and Vpu SINV...
<p>A) Net growth rates of individual <i>gag</i> viruses in competitions. B) Net growth rate differen...
<p>(A) Relative fitness of 3D<sup>G64S</sup> as measured by direct competition. The amount of each v...
<p>Wild-type MEF cells (A) and IRF3/7 knockout MEF cells (B) were infected by Romero (Rom) and Candi...