Dynamic change in histone H3K4me3 is correlated with stress-induced gene expression change.

<p>(A) Black bars (NT) display linear trend for increasing mean gene expression values with increasing H3K4me3 decile. Grey and open bars show gene expression change is greatest among genes that lack H3K4me3 at baseline. (B) Positive correlation (r² = 0.41, <i>p</i> <0.00001) of DXR-induced change in H3K4me3 modification at the TSS with the DXR-induced change in gene expression. (C) Overrepresentation of CTCF, Polycomb, heterochromatic marks among up-regulated genes relative to repressed genes. p53-bound genes were grouped into quintiles based on levels of H3K4me3 at TSS. The frequency of CTCF, polycomb and heterochromatic marks in up-regulated genes relative to their frequencies in down-regulated genes was calculated as enrichment ratio and the enrichment ratio for each quintile is graphed (Y-axis).