Effect size of repeated annual rounds of MDA at varying times of year.

<p>In all cases, the high season is centred at 6 months and MDA is repeated annually with 80% coverage. In B, C and D, the high season is three months long. A: With different lengths of the high season. The black dashed line is the effect size in a non-seasonal setting. B: Components of the effect size. C: Prophylactic and overall MDA effect size with alternative durations of prophylaxis. D: MDA effect size with alternative durations of human infectiousness.