Muscle pathology in 10 month-old diaphragm muscle of wild-type, mdx and mdx/utrn+/- mice.

<p>Extent of total collagen staining (blue) in 10 month-old wild-type (A), mdx (B) and mdx/utrn+/- (C) diaphragms was used as a marker of fibrosis. Proportion of centrally nucleated fibers in the same tissues (D, E, and F) were measured to assess extent of regeneration. Quantification of total collagen staining (G) and proportion of centrally-nucleated myofibers (H) is represented as the mean +SD. * represents p<0.05 and *** represents p<0.001 (scale bar = 100μm).