Putative model of <i>DNMT3B7</i> action in poorly invasive breast cancer cells.

<p>MCF-7 and T-47D cell lines normally have low levels of DNMT3B7 and high expression of E-cadherin. Upon stable transfection of <i>DNMT3B7</i> we observe inhibition of E-cadherin, localization of β-catenin to the nucleus, and tumor progression to a more aggressive phenotype. Future studies will examine the potential for cadherin switching in the presence of DNMT3B7 as well as changes in E-cadherin binding partners, such as catenins, and downstream signaling pathways which may promote tumor progression. Studies examining the role of other aberrant <i>DNMT</i>s will also be imperative to fully understand the role of aberrant <i>DNMT</i> transcripts in breast cancer progression.