Correlations between pathway-specific gene signatures and patient gene expression profiles.

<p>Pearson correlations were performed between each of the thirteen pathway-specific gene signatures and the corresponding probes in the MPH dataset. A. Pathway gene signatures are defined as all probes exhibiting ≥ 2-fold average change in gene expression across all 12 and 24 h time points for a given treatment (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114017#pone.0114017.t002" target="_blank">Table 2</a>). Correlations were repeated across each of the 329 arrays and aligned using the array dendogram from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114017#pone.0114017.g001" target="_blank">Fig. 1</a>. Boxes representing each of the four intrinsic subsets (normal-like = green, fibroproliferative = red, inflammatory = purple, limited = yellow) are shown; arrays not clustering with any defined subset are indicated in black. B. Average Pearson’s correlations for each pathway across each of the intrinsic subsets are provided. C. <i>P</i> values quantifying the enrichment of pathway signatures within individual subsets were calculated based upon the average Pearson’s correlation, with statistically significant correlations highlighted in bold.