Cerebral amyloid angiopathy and microhemorrhaging are unchanged following AFFITOPE-immunization.

<p>The analysis of the incidence of amyloid bearing vessel in AFFITOPE- and control treated animals by assessing 3A5 staining in cerebral vessels reveals no significant differences (A-C). A) Example from a cortical section of a control animal. B) Example from a cortical section of an AD02-treated animal. C) Quantitative analysis demonstrating the average number of 3A5 positive vessels/mm² (avg. +/- SEM) in control (n = 9), and AD02-treated animals (n = 8). The analysis of the incidence of cerebral micro-hemorrhages in these animals by assessing Hemosiderin staining (= Prussian Blue) did not show significant differences at 14 months of age (D-F). D) Example from a cortical section of a control animal. E) Example from a cortical section of an AD02-treated animal. F) quantitative analysis demonstrating the average number of Hemosiderin positive vessels/animal in control (n = 9), and AD02 treated animals (n = 8, respectively); Arrows indicate 3A5 positive vessels, arrowheads indicate amyloid deposits. Scale bar: 50µm; pictures taken at 20x magnification