Long-term maintenance of antigen-specific MBCs is impaired in CDH17^-/- mice.

<p>(A) Antigen-specific IgG1⁺ MBCs (Lin^-B220⁺IgD^-IgM^-CD38⁺IgG1⁺NIP⁺) obtained from CDH17^-/- mice and their WT littermates at 52 weeks after primary immunization with NP-CGG in alum were analyzed by flow cytometry. Numbers represent the percentage (%) of the indicated cell populations in the respective parental gates (shown on top of the panels). (B) The percentages of antigen-specific IgG1⁺ MBCs in their respective B220⁺ parental gate are plotted on a bar graph. The number of weeks post-immunization are shown for each bin. Each symbol represents an individual mouse (n = 6 (Week 0); n = 18 (Weeks 2–6); n = 19 (Weeks 50–67); **P≤0.01 (Mann-Whitney U-test)).