Differences in brain activation between high- and low-sensitization responders during post-burn mechanical noxious stimulation.

<p>Group analysis showing differences in brain activation by BOLD fMRI between high- and low-sensitization responders. Activity is displayed upon standardized inflated brain figures with red areas showing regions-of-interest (ROI) with increased activation and blue areas showing ROI’s with decreased activation. The cartoon on the right illustrates the stimulation zones for the pin-prick stimulation. <b>A: Secondary hyperalgesia</b>: We found significant differences in brain activation between high- and low-sensitization responders after stimulation inside the secondary hyperalgesia area with more activation of the right post-central gyrus, left precuneus, left posterior cingulate cortex, right parahippocampal gyrus, right caudate nucleus and less activation of right precuneus in high- compared to low-sensitization responders. <b>B: Primary hyperalgesia</b>: After stimulation inside the primary hyperalgesia areas we found less activation in the left precentral gyrus and anterior lobe of cerebellum <i>(not shown)</i>.