Functionally grouping of genes with laminar organization.

<p>(A) Enriched functional clusters of gene ontology (GO) and KEGG pathway terms. Overrepresented annotations were identified using an overrepresentation analysis in GOElite [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004032#pcbi.1004032.ref102" target="_blank">102</a>]. Colors reflect terms clustered based on kappa similarity [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004032#pcbi.1004032.ref103" target="_blank">103</a>]. Only the most significant annotations (FDR < 0.01) that are sufficiently different from other terms in cluster (kappa score < 0.7) are shown. (B) Colors indicate the log₂ fold enrichment of the term in the layer-specific list, or lists for individual layers, compared with all MEC-expressed genes. Asterisks indicate significance at * α = 0.05, ** α = 0.01, *** α = 0.001. (C) Colors represent the normalized proportion of high-intensity (≥ 2 x mINT^MEC) pixels in each layer for genes in each of the indicated overrepresented groups. Data were normalized by dividing the proportion for each layer by the sum across layers.