NAC mitigates cocaine-induced toxicity.

<p>Measurements of cell viability with NAC pretreatment (<i>n</i> = 12, <b>A</b>) or post NAC exposure (<i>n</i> = 16, <b>B</b>) and total GSH levels (<i>n</i> = 8–12, <b>C</b>) with NAC pretreatment (5 mM, 30 min) followed by exposure to the indicated concentrations of cocaine for 1h. Data represent mean ± S.E.M. (<i>n</i> = number of assays), *<i>P</i><0.05, **<i>P</i><0.01–0.001 significance of comparison with corresponding control; ^##<i>P</i><0.001 significance of comparison between cocaine alone and cocaine + NAC.