Amygdala-prefrontal connectivity in school-age children who met criteria for preschooler anxiety compared to non-anxious children.

<p>All groups were included in the model, thus these images depict the unique contribution of each disorder controlling for comorbidity with the other disorders. <b>(A)</b> Ventral prefrontal regions, including the ventromedial prefrontal cortex and orbital frontal cortex, displaying less negative connectivity with the amygdala to angry faces in social phobia (N = 11). <b>(B)</b> Dorsal prefrontal regions, including the dorsomedial, dorsolateral, and ventrolateral prefrontal cortex, displaying less negative connectivity with the amygdala to fearful faces in generalized anxiety disorder (N = 15). <b>(C)</b> Ventral prefrontal regions, including the ventromedial and orbital frontal cortices, depicting less negative connectivity (blue) with the amygdala and dorsomedial prefrontal regions depicting greater positive connectivity (yellow) with the amygdala to angry faces in separation anxiety disorder (N = 10). <b>(D)</b> Summary of PPI connectivity pattern, with an up-facing arrow denoting regions where there is an increase in the strength of the positive or negative connection in the anxiety subgroup, as compared to non-anxious children, and regions where there is a decrease in the strength of the positive or negative connection in the anxiety subgroup denoted with a down-facing arrow.