Unsupervised two-way hierarchical cluster analysis with Euclidian distance was performed to classify normal and cancerous urothelial tissue samples.

<p>The log2-fold-change was used to construct the heatmap which indicates that a microRNA expression profiling allows differentiation of normal ureter and urothelial carcinoma tissue. The samples from normal urothelial tissue are coded with “N”, the cancer samples with “T”. The Boxplot diagrams indicate relative levels of each target microRNA.