Kinetic behaviour of synaptic AMPARs.

<p>(<b>A</b>) The blue trace shows the average synaptic current, which reaches its peak within fractions of ms (n = 7). The black bar represents the depolarisation of the pre-synapic terminal. (<b>B</b>) Kinetics of the subconductance states of an AMPA receptor population (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116616#pone.0116616.s005" target="_blank">S4 Supporting model</a>). Left plot, deterministic simulation of a population of GluA3/GluK2 receptors by 1 μM of agonist. Right plot, stochastic simulation of a population of 50 receptors. Only the most populated states are represented for sake of clarity.