Effect of short-term insulin therapy on glycemic control.

<p>(A) and (B) Mice fed a HFD showed worse GTT performance, when compared to that of mice fed a LFD (***p<0.001, and *p<0.05, H vs. L). (C) and (D) Insulin therapy significantly enhanced GTT performance in HFD mice, in comparison to that of sham controls (***p<0.001, **p<0.01, and *p<0.05, HI vs. HS). (E) and (F) At the end of the experiment, insulin-treated mice that switched to a LFD after treatment demonstrated significantly better GTT performance, in comparison to that of sham controls (*p<0.05, HLI vs. HLS at 15 and 30 min). Conversely, insulin-treated mice that were kept on a HFD until the end of the experiment exhibited much worse GTT performance, in comparison to that of mice switched to the LFD (**p<0.01, and *p<0.05, HHI vs. HLI).