Renalase protected against oxidative stress and apoptosis in vivo.

<p>A, LDH release of HK2 cells treated with Ioversol. B, apoptosis of HK2 cells treated with Ioversol. C, ROS levels of HK2 cells treated with H₂O₂. D, Caspase-3 activities of HK2 cells treated with H₂O₂. E, apoptosis of HK2 cells treated with H₂O₂. Iov, ioversol; Veh, Vehicle; Ren0.6, renalase 0.6 µg/ml; Ren6, renalase 6 µg/ml; Ren60, renalase 60µg/ml. The number of repeated wells is 6 in each group. **P<0.01, vs CTL group; #P<0.05, ##P<0.01 vs Veh group; ^▲▲P<0.01, vs CTL (Kruskal-Wallis with Dunn’ compensation).