MiR-1178 promotes tumorigenesis in PANC-1 and BxPC-3 cells.

<p>(A) qRT-PCR showed that after transfecting cells with the miR-1178 mimics or the inhibitor, the expression of miR-1178 was significantly up-regulated or down-regulated, respectively. (B) A CCK-8 assay showed that miR-1178 over-expression promoted the proliferation of PANC-1 and BxPC-3 cells, while the down-regulation of miR-1178 suppressed cell proliferation. (C) The up-regulation of miR-1178 facilitated the G1/S transition in PANC-1 and BxPC-3 cells. In contrast, a G1/S cell cycle arrest was observed after miR-1178 inhibition. The data are presented as the means ± SD. * <i>P</i>＜0. 05, ** <i>P</i> < 0. 01.