Urinary and tissue GAG levels.

<p>A) MPS I mice treated from 6 to 8 months with 1.2mg laronidase/kg every two weeks (n = 10). Urine was collected 1 day post injections. **P<0.01, ANOVA and Tukey. B) Comparison between urinary GAG from 8-month old wild-type (normal, n = 4), MPS I (n = 3) and treated MPS I mice (ERT 6–8mo, n = 10), 1 day after last injection. Treated mice achieve normal GAG level (dotted lines) as soon as the second injection. C) Tissue GAG from 8-month old normal (n = 4/5), MPS I (n = 5–6) and ERT 6–8mo (n = 10) mice collected two weeks after last injection. #P<0.05, Kruskal-Wallis and Mann-Whitney <i>post hoc</i>. ***P<0.001 ANOVA and Tukey <i>post hoc</i>.