Intranasal delivery of anti-IL-9 mAb successfully neutralized IL-9 in the lung.

<p>C57BL/6 mice were intranasally administered with 10μg of either anti-mouse IL-9 mAb or isotype control antibody at day -1 (one day before), day 0, day 2 following Cm (1×10³ IFUs) lung infection. On day 3 post-infection, mice were sacrificed and lung homogenates were prepared to detect IL-9 protein by ELISA. One representative experiment of two independent experiments (four mice in each group in each experiment) is shown. The results are shown as mean ± SD (**, p＜0.01).