Genetic association results for alleles at 29 SNPs with the area under curve calculated by summing the combined toxicity measures on days 0–7.

<p>The SNP ID, genomic position (based on NCBI Build 37), minor allele frequency (MAF), and the <i>p</i>-value (uncorrected for multiple testing) for the allelic association with the combined toxicity measure are shown. The annotation indicates the location of the SNP (intron, 5′ or 3′ UTR), and the amino acid residue altered by the SNP (because of alternative <i>ABCB5</i> transcripts, more than one location is indicated for some SNPs). All <i>p</i>-values < 0.05 are in bold. To account for multiple testing a permutation test was performed for each SNP, and the <i>p</i>-value is shown in a separate column. Of note, rs17143212 is a missense SNP (Thr131ILE) that it is the only SNP with a significant <i>p</i>-value in the permutation test. This indicates that its association with the area under the curve (AUC) remains significant even after accounting for the fact that 29 SNPs were simultaneously tested.</p><p>Genetic association results for alleles at 29 SNPs with the area under curve calculated by summing the combined toxicity measures on days 0–7.