Mutation in the cyclin B-associated kinase CDK-1 suppresses <i>par-2</i>(RNAi) lethality and polarity defects.

<p>(A) Graph reporting the viability of embryos of the specified genotypes after control(RNAi) or <i>par-2</i>(RNAi) treatment. The values correspond to the mean percentage of hatching embryos over the total number of embryos ± SEM over three independent assays performed at 16°C. (B) DIC images from time-lapse movies of <i>par-2</i>(RNAi)-depleted embryos grown at 16°C undergoing first (left) and second (right) division. In all panels, anterior is to the left. Scale bar is 10μm. Black arrowheads indicate centrosome positions and white arrowheads point to sites of membrane ingression during cytokinesis. (C-D) Graphs reporting the measurements for spindle position (C) and asynchrony duration (D) in embryos of the specified genotypes grown at 16°C. Error bars represent standard deviation over the specified number of events (n). In all panels, asterisks indicate statistical significance with control animals (p≤0.05, Student’s t-test).