Decreased colonic contractility in <i>Nrp1^SMKO</i>.

<p>Organ bath experiments showing the colonic contractile response to increasing doses of KCl (A) and CCh (B) in <i>Nrp1^SMKO</i> and <i>Nrp1^+/−</i> mice (means±SEM). A significant difference in the contractile tension in response to KCl was observed at 80mM (A, *<i>P</i> = .0359, n = 3). (B) Colonic segments of <i>Nrp1^SMKO</i> had a significantly reduced contractility in response to CCh at 3μM (*<i>P</i><.05, **<i>P</i> = .0088, n = 4). (C) Representative spontaneous contractions are shown for colonic segments from three different <i>Nrp1^SMKO</i> and <i>Nrp1^+/−</i> littermates.