Immunohistochemical analysis demonstrates significantly reduced CD11b positive cell counts with Serp-1 treatment in TAI grafts in SCID mice at 4 weeks (n = 5–10).

<p>(A) CD11b⁺ staining of GCA^pos sections in Saline + PBMC treated mice. Brown stained areas are positively stained cells (marked by arrows) (B) CD11b⁺ staining of GCA^pos sections in TAI grafts with Serp-1 + PBMC treatment. (C) GCA^pos or GCA^neg engrafted sections without PBMC did not show a significant change for CD3, CD11b, CCR6 nor CD83 stained cell counts (n = 3 each for GCA^pos or GCA^neg). (D) CD11b⁺ cells were significantly reduced by Serp-1 treatment after PBMC transfusion when combining data for GCA^pos and GCA^neg. No difference in CD3⁺, CCR6⁺, and CD83⁺ cell counts were detected for combined data (n = 5–10). Magnification- 400X.