Nitric oxide production by resident macrophages is dependent on IRF-1.

<p>Resident macrophages (2x10⁵/well) from wild type or IRF-1 deficient mice (IRF-1-/-) were incubated with L929 cells (3.5x10⁴/well) in the presence of the indicated concentrations of IFNγ. After 48 hours of incubation, cell supernatants were used for nitrite concentration determination by Reaction. Data represent the means ± SD (n = 5/group).