Effects of miR-185 on β-cell function and cell growth.

<p>Loss of miR-185 reduced total insulin content (A), inhibited glucose stimulated insulin secretion (B), reduced cell proliferation and viability (C), and stimulated cell apoptosis (D). Inversely, elevated miR-185 increased total insulin content (E), glucose stimulated insulin secretion (F), promoted cell proliferation and viability (G), and repressed cell apoptosis (H). (**P<0.01, *P<0.05, Figure is representative of 3 experiments with similar results.)