Hypothalamic volumes corrected for ICV.

<p>Boxplots illustrate hypothalamic volumes when corrected for ICV for the control, pre-HD and symp-HD groups at baseline. A four-way ANOVA revealed only a significant effect of ICV (ICV: F_(1,96) = 16.826, p = 0.001) but not for the other parameters (group: n.s (F_(2,96) = 0.597, p = 0.553), sex: F_(1,96) = n.s (F = 3.804, p = 0.054), age: n.s. (F_(1,96) = 0.165, p = 0.685)). Once adjusted for ICV, a three-way ANOVA was performed to assess the effect of HD gene status, sex and age on the hypothalamic volume estimates. No significant effects were found (group: n.s (F_(2,92) = 0.838, p = 0.436), sex: F_(1,92) = n.s (F = 0.927, p = 0.338), and age: n.s. (F_(1,92) = 0.576, p = 0.564)).