DNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.

<p>¹HV, Healthy volunteers</p><p>²PS, Platinum-sensitive patients</p><p>³PR, Platinum-resistant patients</p><p>⁴PBMCs that are defined as having more than 5 foci per cell, expressed as a fraction of 100</p><p>⁵Olive Tail Moment (OTM) values, arbitrary units</p><p>⁶AUC values, expressed as (% of γH2AX positive staining cells) x (carboplatin dose)</p><p>⁷AUC values (expressed as OTM x carboplatin dose)</p><p>⁸t_1/2 for γH2AX foci removal, in h</p><p>⁹t_1/2 values for carboplatin-induced damage repair, in h</p><p>¹⁰apoptosis rates expressed as doses of carboplatin inducing apoptosis (as defined in the Materials and Methods section)</p><p>¹¹AUC values, expressed as (% of pan-nuclear staining cells) x (carboplatin dose)</p><p>¹²Wilcoxon rank-sum tests</p><p>DNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.