<p>FACS analysis and frequencies of T-bet<sup>+</sup> cells within Foxp3<sup>+</sup>CD4<sup>+</sup> T cell population from spleen and LP in <i>CD11c</i><sup><i>cre</i></sup><i>IL27p28</i><sup><i>fl/fl</i></sup> mice and WT littermate controls <b>(A)</b> at steady state or <b>(B)</b> 8 days after <i>T</i>. <i>gondii</i> infection. FACS plots are representative of three independent experiments (*p<0.05; **p<0.01; ***p<0.001).</p
Upon microbial challenge, helper T cells orchestrate complex inflammatory responses that are specifi...
Interleukin (IL)-27 is a heterodimeric cytokine with potent inhibitory properties. Thus, mice that l...
<p>(A) Flow cytometric analysis of representative naïve (top row) and infected mice (8 days post-inf...
<p><b>(A, B)</b> CD4<sup>+</sup>CXCR3<sup>-</sup>GFP<sup>+</sup> Treg cells isolated from naive Foxp...
<p><b>(A)</b> GSEA of T cell activation pathway genes (GO:0050863) between IFNγR2-deficient and—suff...
<p><i>CD11c</i><sup><i>cre+</i></sup><i>IL27p28</i><sup><i>fl/fl</i></sup>, <i>LysM</i><sup><i>cre+<...
<p>Expression of p28, EBi3, IL27 hyperkine, or GFP control were induced in vivo using minicircle DNA...
SummaryInterferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that li...
<p><b>A</b>) IFNγ quantification in the serum from non-infected (Ninf) and from 4 wpi WT and P25 mic...
<p>Absolute numbers of thymic Treg (CD3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>)...
<p>Single-cell spleen suspensions from <i>C</i>. <i>sinensis</i>-infected and control mice (NC) were...
<p>Flow cytometry showing the percentages (A, B) and absolute numbers (C) of CD4<sup>+</sup>CD25<sup...
Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.Tumor nec...
<p><i>Il-27r</i>α<sup>-/-</sup> or WT (C57BL/6) mice were infected with MCMV and spleen and salivary...
<p>Mice were given anti-CD25 depleting antibody (CD25<sup>+</sup> cell depleted) or PBS (Control) on...
Upon microbial challenge, helper T cells orchestrate complex inflammatory responses that are specifi...
Interleukin (IL)-27 is a heterodimeric cytokine with potent inhibitory properties. Thus, mice that l...
<p>(A) Flow cytometric analysis of representative naïve (top row) and infected mice (8 days post-inf...
<p><b>(A, B)</b> CD4<sup>+</sup>CXCR3<sup>-</sup>GFP<sup>+</sup> Treg cells isolated from naive Foxp...
<p><b>(A)</b> GSEA of T cell activation pathway genes (GO:0050863) between IFNγR2-deficient and—suff...
<p><i>CD11c</i><sup><i>cre+</i></sup><i>IL27p28</i><sup><i>fl/fl</i></sup>, <i>LysM</i><sup><i>cre+<...
<p>Expression of p28, EBi3, IL27 hyperkine, or GFP control were induced in vivo using minicircle DNA...
SummaryInterferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that li...
<p><b>A</b>) IFNγ quantification in the serum from non-infected (Ninf) and from 4 wpi WT and P25 mic...
<p>Absolute numbers of thymic Treg (CD3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>)...
<p>Single-cell spleen suspensions from <i>C</i>. <i>sinensis</i>-infected and control mice (NC) were...
<p>Flow cytometry showing the percentages (A, B) and absolute numbers (C) of CD4<sup>+</sup>CD25<sup...
Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.Tumor nec...
<p><i>Il-27r</i>α<sup>-/-</sup> or WT (C57BL/6) mice were infected with MCMV and spleen and salivary...
<p>Mice were given anti-CD25 depleting antibody (CD25<sup>+</sup> cell depleted) or PBS (Control) on...
Upon microbial challenge, helper T cells orchestrate complex inflammatory responses that are specifi...
Interleukin (IL)-27 is a heterodimeric cytokine with potent inhibitory properties. Thus, mice that l...
<p>(A) Flow cytometric analysis of representative naïve (top row) and infected mice (8 days post-inf...