<div><p>Malaria infection begins when a female <i>Anopheles</i> mosquito injects <i>Plasmodium</i> sporozoites into the skin of its host during blood feeding. Skin-deposited sporozoites may enter the bloodstream and infect the liver, reside and develop in the skin, or migrate to the draining lymph nodes (DLNs). Importantly, the DLN is where protective CD8<sup>+</sup> T cell responses against malaria liver stages are induced after a dermal route of infection. However, the significance of parasites in the skin and DLN to CD8<sup>+</sup> T cell activation is largely unknown. In this study, we used genetically modified parasites, as well as antibody-mediated immobilization of sporozoites, to determine that active sporozoite migration to the DLN...
Protective immune responses against malaria are induced by immunization with radiation-attenuated Pl...
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antige...
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infe...
Malaria infection begins when a female Anopheles mosquito injects Plasmodium sporozoites into the sk...
The success of immunization with irradiated sporozoites is unparalleled among the current vaccinatio...
The success of immunization with irradiated sporozoites is unparalleled among the current vaccinatio...
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antige...
Following Anophelesmosquito-mediated introduction into a human host, Plasmodium parasites infect hep...
<p>Sporozoite-mediated delivery of malaria antigens to the DLNs is required for CD8<sup>+</sup> T ce...
Following Anopheles mosquito-mediated introduction into a human host, Plasmodium parasites infect he...
Following Anopheles mosquito-mediated introduction into a human host, Plasmodium parasites infect he...
The onset of an adaptive immune response provides the signals required for differentiation of antige...
Malaria, a disease caused by parasites of the Plasmodium genus, begins when Plasmodium-infected mosq...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infectio...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infectio...
Protective immune responses against malaria are induced by immunization with radiation-attenuated Pl...
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antige...
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infe...
Malaria infection begins when a female Anopheles mosquito injects Plasmodium sporozoites into the sk...
The success of immunization with irradiated sporozoites is unparalleled among the current vaccinatio...
The success of immunization with irradiated sporozoites is unparalleled among the current vaccinatio...
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antige...
Following Anophelesmosquito-mediated introduction into a human host, Plasmodium parasites infect hep...
<p>Sporozoite-mediated delivery of malaria antigens to the DLNs is required for CD8<sup>+</sup> T ce...
Following Anopheles mosquito-mediated introduction into a human host, Plasmodium parasites infect he...
Following Anopheles mosquito-mediated introduction into a human host, Plasmodium parasites infect he...
The onset of an adaptive immune response provides the signals required for differentiation of antige...
Malaria, a disease caused by parasites of the Plasmodium genus, begins when Plasmodium-infected mosq...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infectio...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infectio...
Protective immune responses against malaria are induced by immunization with radiation-attenuated Pl...
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antige...
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infe...