Evolutionary changes in p53 transactivation specificity.

<p>Transactivation potentials for the ten REs tested are presented as radar plot graphs in Log₁₀ scale, relative to the results obtained with CON1 (set to 1). The resulting images represent the transactivation specificity for the indicated p53 proteins and that of human p53 is also overlaid (gray line) in every panel to facilitate comparisons. The yeast-based transactivation results at 0.064% of galactose concentration were used. Results obtained at 0.008% galactose are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116177#pone.0116177.s001" target="_blank">S1 File</a>.