Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa

Kevin T. O’Brien (1657060)
Joseph G. Noto (1657057)
Luke Nichols-O’Neill (1657063)
Lark J. Perez (1276848)

Publication date

February 2015

DOI

Abstract

Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14

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Potent Irreversible Inhibitors of LasR Quorum Sensing in <i>Pseudomonas aeruginosa</i>

Abstract

Extracted data

Potent Irreversible Inhibitors of LasR Quorum Sensing in <i>Pseudomonas aeruginosa</i>

Abstract

Extracted data

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