Survival of the wild-type <i>S</i>. <i>aureus</i> strain SH1000 and its derivative <i>msr</i> mutant cells in mouse.

<p>Approximately 1.0X10⁸ CFUs (predominantly mutant cells) were injected intra-peritoneally into mice. Three mice were sacrificed at 8 and 24 h post-injection. Closed circles represent the fraction of wild-type SH1000 and the open circles represent the <i>msr</i> mutant bacteria recovered from murine spleens (A) and murine livers (B) at 8 and 24 h post infection. Values at 0 h indicate the fraction of <i>msr</i> mutants and isogenic wild-type cells in the injected inoculum. Values indicate the average of three independent experiments ± standard deviation (* significant at <i>p</i>≤.05).