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Changes in islet gene expression upon MSC co-culture: Downregulated genes.

Gumpei Yoshimatsu (697620)
Naoaki Sakata (518975)
Haruyuki Tsuchiya (697621)
Takashi Minowa (460180)
Taro Takemura (508882)
Hiromi Morita (252261)
Tatsuo Hata (697622)
Masahiko Fukase (697623)
Takeshi Aoki (518976)
Masaharu Ishida (126995)
Fuyuhiko Motoi (518977)
Takeshi Naitoh (518978)
Yu Katayose (518979)
Shinichi Egawa (518980)
Michiaki Unno (518981)

Publication date

February 2015

DOI

10.1371/journal.pone.0117561.t003

Abstract

<p>Changes in islet gene expression upon MSC co-culture: Downregulated genes.</p

Extracted data

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The effects of different treatments on the expressions of survival, proliferation, and angiogenesis related signal proteins.

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Ahn, Yb
Xu, G
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Toschi, E
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Sgroi, Dc
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Genes that were downregulated in MafA KO islets in both transcriptome datasets.

PLOS ONE (2189197)

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<p>Genes that were downregulated in MafA KO islets in both transcriptome datasets.</p

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Adetola Adesida (320980)
Nadr Jomha (320981)
A. M. James Shapiro (320983)
Gregory S. Korbutt (320986)

February 2013

<p>A-C) 500 Islets, D-F) 500 Islets + cytokines, G-I) 500 Islets +1.0×10<sup>6</sup> bMSCs, + cytoki...

Statistically significant altered Biological Processes in islets.

Sarita Negi (186064)
Arif Jetha (186065)
Reid Aikin (177878)
Craig Hasilo (186066)
Rob Sladek (160663)
Steven Paraskevas (186067)

January 2012

<p>The differentially expressed genes (p<0.05, fold change>2) from d0-islets and d3-islets were clas...

Gene dependent differences in expression changes induced by IFN-γ applied to already mature or maturing cells.

Michael A. Ellison (789371)
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The effects of different treatments on the expressions of survival, proliferation, and angiogenesis related signal proteins.

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Differentially regulated genes annotated as cell-cycle associatedFold change.

Yasuko Kamisugi (12356)
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August 2016

<p>Differentially regulated genes annotated as cell-cycle associatedFold change.</p

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection

Ahn, Yb
Xu, G
Marselli, Lorella
Toschi, E
Sharma, A
Bonner Weir, S
Sgroi, Dc
Weir, Gc

January 2007

AIMS/HYPOTHESIS: The process of islet isolation can cause chemical and mechanical injury to beta cel...

Genes that were downregulated in MafA KO islets in both transcriptome datasets.

PLOS ONE (2189197)

November 2014

<p>Genes that were downregulated in MafA KO islets in both transcriptome datasets.</p

IFNγ, Il-1β, and TNFα-induced changes in H3K4me1 enrichment correspond to changes in islet transcription.

Bryan R. Tennant (295330)
Peter Hurley (818610)
Jasmine Dhillon (818612)
Amol Gill (818613)
Cheryl Whiting (818615)
Brad G. Hoffman (53807)

October 2015

<p>(A) Scatter plot of the FPKM of identified transcripts in untreated or IFNγ, Il-1β, and TNFα (Cyt...

Glucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia

Ottosson-Laakso, Emilia
Krus, Ulrika
Storm, Petter
Prasad, Rashmi B
Oskolkov, Nikolay
Ahlqvist, Emma
Fadista, João
Hansson, Ola
Groop, Leif
Vikman, Petter

September 2017

Dysregulation of gene expression in islets from type 2 diabetic patients might be causally involved ...

Function, ANOVA p-values and fold changes of the top ten genes upregulated in freshly isolated (d0) and 3-days cultured islets (d3).

Sarita Negi (186064)
Arif Jetha (186065)
Reid Aikin (177878)
Craig Hasilo (186066)
Rob Sladek (160663)
Steven Paraskevas (186067)

January 2012

a<p>Genes common between top 10 upregulated genes from d0-islets and d3-islets.</p

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition

Perez-Alcantara, M
Honoré, C
Wesolowska-Andersen, A
Gloyn, A
McCarthy, M
Hansson, M
Beer, N
van de Bunt, M

January 2018

Aims/hypothesis Most type 2 diabetes-associated genetic variants identified via genome-wide associat...

Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

Jalal Taneera
Petter Storm
Leif Groop

January 2014

Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is un...

Endothelial cells promote upregulation of ECM-associated genes in islet cultures.

Keren Kaufman-Francis (151484)
Jacob Koffler (151491)
Noa Weinberg (151497)
Yuval Dor (44175)
Shulamit Levenberg (151504)

July 2012

<p>Quantitative real-time PCR analyses of the ECM-associated (<b>a</b>) <i>ITGB1</i> and (<b>b</b>) ...

Significantly upregulated or downregulated genes of <i>in vitro</i> M cells compared with Caco-2 cells.

Ke-Chuan Wang (95604)
Chih-Hung Huang (2606029)
Ching-Jou Huang (435832)
Shiuh-Bin Fang (2606026)

April 2016

<p>Significantly upregulated or downregulated genes of <i>in vitro</i> M cells compared with Caco-2 ...

Chronic hyperglycemia alters the β-cell specific gene expression in pancreatic islets.

In-Su Cho (174455)
Miyoung Jung (174459)
Ki-Sun Kwon (171027)
Eunpyo Moon (174464)
Jang-Hyeon Cho (174468)
Kun-Ho Yoon (174472)
Ji-Won Kim (174475)
Young-Don Lee (174478)
Sung-Soo Kim (174479)
Haeyoung Suh-Kim (174480)

April 2012

<p>(<b>A</b>) Rat islet cells were cultured in the presence of 5 mM or 30 mM glucose for 8 days, and...

Protection of human islets from cytokine induced apoptosis by bone marrow derived MSCs.

Telford Y. Yeung (320974)
Karen L. Seeberger (320976)
Tatsuya Kin (320978)
Adetola Adesida (320980)
Nadr Jomha (320981)
A. M. James Shapiro (320983)
Gregory S. Korbutt (320986)

February 2013

<p>A-C) 500 Islets, D-F) 500 Islets + cytokines, G-I) 500 Islets +1.0×10<sup>6</sup> bMSCs, + cytoki...

Statistically significant altered Biological Processes in islets.

Sarita Negi (186064)
Arif Jetha (186065)
Reid Aikin (177878)
Craig Hasilo (186066)
Rob Sladek (160663)
Steven Paraskevas (186067)

January 2012

<p>The differentially expressed genes (p<0.05, fold change>2) from d0-islets and d3-islets were clas...

Gene dependent differences in expression changes induced by IFN-γ applied to already mature or maturing cells.

Michael A. Ellison (789371)
Christy M. Gearheart (789373)
Christopher C. Porter (252357)
Daniel R. Ambruso (789375)

October 2017

<p>Gene dependent differences in expression changes induced by IFN-γ applied to already mature or ma...

The effects of different treatments on the expressions of survival, proliferation, and angiogenesis related signal proteins.

Yang Li (7082)
Wujun Xue (326652)
Hongbao Liu (326650)
Ping Fan (378817)
Xiaohong Wang (93777)
Xiaoming Ding (280656)
Xiaohui Tian (336316)
Xinshun Feng (378818)
Xiaoming Pan (378819)
Jin Zheng (196007)
Puxun Tian (378820)
Chenguang Ding (378821)
Xiaohu Fan (378822)

February 2013

<p>Western blot analysis investigated the control of survival, proliferation, and angiogenesis relat...

Differentially regulated genes annotated as cell-cycle associatedFold change.

Yasuko Kamisugi (12356)
John W. Whitaker (728679)
Andrew C. Cuming (12357)

August 2016

<p>Differentially regulated genes annotated as cell-cycle associatedFold change.</p

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection

Ahn, Yb
Xu, G
Marselli, Lorella
Toschi, E
Sharma, A
Bonner Weir, S
Sgroi, Dc
Weir, Gc

January 2007

AIMS/HYPOTHESIS: The process of islet isolation can cause chemical and mechanical injury to beta cel...