Effects of miR-572 on the cognitive function of the POCD rat model.

<p>A. Detection of miR-572 in rat peripheral blood (left) and in situ hybridization detection of miR-572 expression in the rat hippocampus area. B. Schematics of the water maze routes. C. After surgery, the POCD rats had a longer latency in finding the platform in the water maze test compared to the time needed before surgery. D. Real-time quantitative PCR detection of miR-572 in the peripheral blood of POCD rats and non-POCD rats before and after surgery. In POCD rats, the postoperative miR-572 expression in the peripheral blood was lower than the preoperative level (left), while the non-POCD rats did not show significant changes in the miR-572 expression before and after surgery (right). E. Schematic diagram of the water maze route for the POCD rats after treatment with the miR-572 inhibitor (left). After treatment, the latency of the rats in the water maze test was significantly reduced (middle), whereas the control group showed no significant improvement (right). F. In situ hybridization detection found that after injection of inhibitors, the expression level of miR-572 in the rat hippocampus was decreased. pre, preoperation; pos, postoperation.