Firing properties of dentate gyrus granule cells in response to ramp currents.

<p>A, representative spike firings of DG granule cells in response to ramp current clamp. Aβ microinjection into the EC induced: a significant increase in latency of the first AP (B), a significant increase of current required to evoke the first AP (C), and a significant decrease in AP numbers (D). Treatment by isradipine and nimodipine preserved granule cells from these changes. *p < 0.05 and **p < 0.01 compared with the control cells. ^#p < 0.05 and ^##p < 0.01 compared to the EC-Aβ group. Control and EC-Aβ groups, n = 6 cells/ 4 rats; EC-Aβ + ISR, n = 5 cells/ 4 rats; EC-Aβ + NIM, n = 6 cells/ 4 rats.