Intratumoral injection of FDGlcU in mice treated with <i>E. coli</i> (lux/βG) enhances glucuronide hydrolysis.

<p>(A) NOD/SCID mice bearing HCT116 tumors were i.v. injected with 4 x 10⁷ c.f.u. <i>E. coli</i> (lux/βG) or intratumorally-injected with 10⁹ p.f.u. Ad/mβG on two consecutive days. On day 4, 500 μg FDGlcU was i.v. injected into mice or 5 μg FDGlcU was directly injected into tumors. After 30 min, the fluorescence of the tumors were detected on an IVIS Spectrum (n = 3). (B) The region of the interesting (ROI) of mice treated as in panel A were analyzed (n = 3). The Y-axis indicates the mean FDGlcU fluorescence intensity (n = 3). Bars, s.d. * P < 0.05; n.s. no significant difference.