Analysis of IFN inducible gene expression in liver by mIFNα2-dAb fusions.

Pharmacokinetic analysis of mIFNα2-dAb fusions in serum following intravenous administration.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Targeted mIFNα2 (solid line) and non-targeted mIFNα2 isotype control dAb (dotted line) were admin...

Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

Mitsuru Ando
Yuki Takahashi
Takuma Yamashita
Mai Fujimoto
Makiya Nishikawa
Yoshihiko Watanabe
Yoshinobu Takakura

January 2014

Sustained gene delivery of interferon (IFN) γ can be an effective treatment, but our previous study ...

Response of different HyBNAR mouse strains to human IFNβ stimulation.

Daniel Harari (507866)
Renne Abramovich (507867)
Alla Zozulya (507868)
Paul Smith (175833)
Sandrine Pouly (151681)
Mario Köster (441538)
Hansjörg Hauser (48091)
Gideon Schreiber (260836)

January 2014

Two representative mice from four independent transgenic HyBNAR strains were injected IV. with 40...

Analysis of IFN inducible gene expression in blood by mIFNα2-dAb fusions.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Targeted mIFNα2 and non-targeted mIFNα2 were administered at 2μg/kg and 20μg/kg via intravenous i...

Antiviral efficacy of mIFNα2-dAb fusions and PEGylated mIFNα2 following intravenous administration.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Effect of single-dose liver-targeted IFN-α on liver HBV DNA using Southern blot hybridization (up...

Antagonist activity in mice.

Victoria Urin (767622)
Doron Levin (767623)
Nanaocha Sharma (278534)
Daniel Harari (507866)
Gideon Schreiber (260836)

July 2015

Antagonist activity in mice was determined by their ability to induce or inhibit IFN-induced gene...

Expression of genes encoding IFN-α, IFN-β, and IFN-γ following induction by LIC-pIC in chimeric mice with humanized livers.

Shin-ichiro Nakagawa (395769)
Yuichi Hirata (142223)
Takeshi Kameyama (395770)
Yuko Tokunaga (111299)
Yasumasa Nishito (395771)
Kazuko Hirabayashi (395772)
Junichi Yano (395773)
Takahiro Ochiya (32682)
Chise Tateno (395774)
Yasuhito Tanaka (39138)
Masashi Mizokami (135007)
Kyoko Tsukiyama-Kohara (111301)
Kazuaki Inoue (395775)
Makoto Yoshiba (395776)
Akinori Takaoka (221794)
Michinori Kohara (111313)

March 2013

(A) Experimental schedule in chimeric mice infected with HCV. (B) Serum concentrati...

Liver-targeting of interferon-alpha with tissue-specific domain antibodies.

Edward Coulstock
Jane Sosabowski
Milan Ovečka
Rob Prince
Laura Goodall
Clare Mudd
Armin Sepp
Marie Davies
Julie Foster
Jerome Burnet
Gráinne Dunlevy
Adam Walker

Interferon alpha (IFNα) is used for the treatment of hepatitis C infection and whilst efficacious it...

Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.

Daniel Rycroft
Jane Sosabowski
Edward Coulstock
Marie Davies
John Morrey
Sarah Friel
Fiona Kelly
Robert Hamatake
Milan Ovečka
Rob Prince
Laura Goodall
Armin Sepp
Adam Walker

Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficac...

IFN-λ activates Mx1 gene expression in lung but not liver of IFNAR10/0 mice.

Markus Mordstein (376710)
Georg Kochs (376711)
Laure Dumoutier (376712)
Jean-Christophe Renauld (328418)
Søren R. Paludan (336261)
Kevin Klucher (376713)
Peter Staeheli (76921)

February 2013

(A) Western blot analysis of Mx1 protein levels in lungs of mice at 20 hours post intranasal appl...

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

Edward Coulstock
Jane Sosabowski
Rob Prince
Laura Goodall
Clare Mudd
Marie Davies
Julie Foster
Jerome Burnet
Adam Walker

January 2012

Interferon alpha (IFNa) is used for the treatment of hepatitis C infection and whilst efficacious it...

Relative type III and type I IFN gene transcription in the brain and in the liver of infected C57BL/6 mice.

Caroline Sommereyns (76919)
Sophie Paul (76920)
Peter Staeheli (76921)
Thomas Michiels (76922)

February 2013

aCalculations were as followed: for each mouse, the ratio between type III and type I IFN transcr...

High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes.

Simon P. Fletcher (793613)
Daniel J. Chin (793614)
Lore Gruenbaum (235506)
Hans Bitter (158638)
Erik Rasmussen (793615)
Palanikumar Ravindran (158625)
David C. Swinney (793616)
Fabian Birzele (793617)
Roland Schmucki (793618)
Stefan H. Lorenz (793619)
Erhard Kopetzki (48502)
Jade Carter (793620)
Miriam Triyatni (224702)
Linta M. Thampi (793621)
Junming Yang (793622)
Dalal AlDeghaither (793623)
Marta G. Murredu (793624)
Paul Cote (793625)
Stephan Menne (793626)

September 2015

RNA-Seq data for genes selectively induced by high dose (100 μg) but not by low dose (20 μg) wIFN...

Gene expression of IFN-γ, COX-2, and TNF-α in the liver.

Yuhei Shibata (842072)
Takeshi Hara (113234)
Junji Nagano (455715)
Nobuhiko Nakamura (455719)
Tomohiko Ohno (724800)
Soranobu Ninomiya (842073)
Hiroyasu Ito (455721)
Takuji Tanaka (9733)
Kuniaki Saito (9421)
Mitsuru Seishima (455723)
Masahito Shimizu (455716)
Hisataka Moriwaki (455724)
Hisashi Tsurumi (455722)

January 2016

Expression levels of (A) IFN-γ, (B) COX-2, and (C) TNF-α mRNA in hepatic tumors and in normal liv...

IFNs induce the expression of the IFI16, AIM2, and inflammasome genes.

Sudhakar Veeranki (340846)
Xin Duan (265098)
Ravichandran Panchanathan (340848)
Hongzhu Liu (340849)
Divaker Choubey (340850)

February 2013

(A) Total RNA was extracted from THP-1 cells either left untreated (control) or treated wi...

Pharmacokinetic analysis of mIFNα2-dAb fusions in serum following intravenous administration.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Targeted mIFNα2 (solid line) and non-targeted mIFNα2 isotype control dAb (dotted line) were admin...

Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

Mitsuru Ando
Yuki Takahashi
Takuma Yamashita
Mai Fujimoto
Makiya Nishikawa
Yoshihiko Watanabe
Yoshinobu Takakura

January 2014

Sustained gene delivery of interferon (IFN) γ can be an effective treatment, but our previous study ...

Response of different HyBNAR mouse strains to human IFNβ stimulation.

Daniel Harari (507866)
Renne Abramovich (507867)
Alla Zozulya (507868)
Paul Smith (175833)
Sandrine Pouly (151681)
Mario Köster (441538)
Hansjörg Hauser (48091)
Gideon Schreiber (260836)

January 2014

Two representative mice from four independent transgenic HyBNAR strains were injected IV. with 40...

Analysis of IFN inducible gene expression in blood by mIFNα2-dAb fusions.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Targeted mIFNα2 and non-targeted mIFNα2 were administered at 2μg/kg and 20μg/kg via intravenous i...

Antiviral efficacy of mIFNα2-dAb fusions and PEGylated mIFNα2 following intravenous administration.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Effect of single-dose liver-targeted IFN-α on liver HBV DNA using Southern blot hybridization (up...

Antagonist activity in mice.

Victoria Urin (767622)
Doron Levin (767623)
Nanaocha Sharma (278534)
Daniel Harari (507866)
Gideon Schreiber (260836)

July 2015

Antagonist activity in mice was determined by their ability to induce or inhibit IFN-induced gene...

Expression of genes encoding IFN-α, IFN-β, and IFN-γ following induction by LIC-pIC in chimeric mice with humanized livers.

Shin-ichiro Nakagawa (395769)
Yuichi Hirata (142223)
Takeshi Kameyama (395770)
Yuko Tokunaga (111299)
Yasumasa Nishito (395771)
Kazuko Hirabayashi (395772)
Junichi Yano (395773)
Takahiro Ochiya (32682)
Chise Tateno (395774)
Yasuhito Tanaka (39138)
Masashi Mizokami (135007)
Kyoko Tsukiyama-Kohara (111301)
Kazuaki Inoue (395775)
Makoto Yoshiba (395776)
Akinori Takaoka (221794)
Michinori Kohara (111313)

March 2013

(A) Experimental schedule in chimeric mice infected with HCV. (B) Serum concentrati...

Liver-targeting of interferon-alpha with tissue-specific domain antibodies.

Edward Coulstock
Jane Sosabowski
Milan Ovečka
Rob Prince
Laura Goodall
Clare Mudd
Armin Sepp
Marie Davies
Julie Foster
Jerome Burnet
Gráinne Dunlevy
Adam Walker

Interferon alpha (IFNα) is used for the treatment of hepatitis C infection and whilst efficacious it...

Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.

Daniel Rycroft
Jane Sosabowski
Edward Coulstock
Marie Davies
John Morrey
Sarah Friel
Fiona Kelly
Robert Hamatake
Milan Ovečka
Rob Prince
Laura Goodall
Armin Sepp
Adam Walker

Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficac...

IFN-λ activates Mx1 gene expression in lung but not liver of IFNAR10/0 mice.

Markus Mordstein (376710)
Georg Kochs (376711)
Laure Dumoutier (376712)
Jean-Christophe Renauld (328418)
Søren R. Paludan (336261)
Kevin Klucher (376713)
Peter Staeheli (76921)

February 2013

(A) Western blot analysis of Mx1 protein levels in lungs of mice at 20 hours post intranasal appl...

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

Edward Coulstock
Jane Sosabowski
Rob Prince
Laura Goodall
Clare Mudd
Marie Davies
Julie Foster
Jerome Burnet
Adam Walker

January 2012

Interferon alpha (IFNa) is used for the treatment of hepatitis C infection and whilst efficacious it...

Relative type III and type I IFN gene transcription in the brain and in the liver of infected C57BL/6 mice.

Caroline Sommereyns (76919)
Sophie Paul (76920)
Peter Staeheli (76921)
Thomas Michiels (76922)

February 2013

aCalculations were as followed: for each mouse, the ratio between type III and type I IFN transcr...

High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes.

Simon P. Fletcher (793613)
Daniel J. Chin (793614)
Lore Gruenbaum (235506)
Hans Bitter (158638)
Erik Rasmussen (793615)
Palanikumar Ravindran (158625)
David C. Swinney (793616)
Fabian Birzele (793617)
Roland Schmucki (793618)
Stefan H. Lorenz (793619)
Erhard Kopetzki (48502)
Jade Carter (793620)
Miriam Triyatni (224702)
Linta M. Thampi (793621)
Junming Yang (793622)
Dalal AlDeghaither (793623)
Marta G. Murredu (793624)
Paul Cote (793625)
Stephan Menne (793626)

September 2015

RNA-Seq data for genes selectively induced by high dose (100 μg) but not by low dose (20 μg) wIFN...

Gene expression of IFN-γ, COX-2, and TNF-α in the liver.

Yuhei Shibata (842072)
Takeshi Hara (113234)
Junji Nagano (455715)
Nobuhiko Nakamura (455719)
Tomohiko Ohno (724800)
Soranobu Ninomiya (842073)
Hiroyasu Ito (455721)
Takuji Tanaka (9733)
Kuniaki Saito (9421)
Mitsuru Seishima (455723)
Masahito Shimizu (455716)
Hisataka Moriwaki (455724)
Hisashi Tsurumi (455722)

January 2016

Expression levels of (A) IFN-γ, (B) COX-2, and (C) TNF-α mRNA in hepatic tumors and in normal liv...

IFNs induce the expression of the IFI16, AIM2, and inflammasome genes.

Sudhakar Veeranki (340846)
Xin Duan (265098)
Ravichandran Panchanathan (340848)
Hongzhu Liu (340849)
Divaker Choubey (340850)

February 2013

(A) Total RNA was extracted from THP-1 cells either left untreated (control) or treated wi...

Pharmacokinetic analysis of mIFNα2-dAb fusions in serum following intravenous administration.

Daniel Rycroft (692744)
Jane Sosabowski (381776)
Edward Coulstock (381775)
Marie Davies (381782)
John Morrey (692745)
Sarah Friel (692746)
Fiona Kelly (242375)
Robert Hamatake (692747)
Milan Ovečka (381777)
Rob Prince (381778)
Laura Goodall (381779)
Armin Sepp (381781)
Adam Walker (381786)

February 2015

Targeted mIFNα2 (solid line) and non-targeted mIFNα2 isotype control dAb (dotted line) were admin...

Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

Mitsuru Ando
Yuki Takahashi
Takuma Yamashita
Mai Fujimoto
Makiya Nishikawa
Yoshihiko Watanabe
Yoshinobu Takakura

January 2014

Sustained gene delivery of interferon (IFN) γ can be an effective treatment, but our previous study ...

Response of different HyBNAR mouse strains to human IFNβ stimulation.

Daniel Harari (507866)
Renne Abramovich (507867)
Alla Zozulya (507868)
Paul Smith (175833)
Sandrine Pouly (151681)
Mario Köster (441538)
Hansjörg Hauser (48091)
Gideon Schreiber (260836)

January 2014

Two representative mice from four independent transgenic HyBNAR strains were injected IV. with 40...

Analysis of IFN inducible gene expression in liver by mIFNα2-dAb fusions.

Abstract

Extracted data

Analysis of IFN inducible gene expression in liver by mIFNα2-dAb fusions.

Abstract

Extracted data

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