<p>Panel A; rucaparib (closed squares), nicotinamide (open squares) and ML-9 (open triangles) inhibit smooth muscle contraction in PE-constricted rat tail artery. Artery sections were constricted using 10 μM PE before perfusion with a solution containing 10 μM PE plus the relevant concentration of drug. Panel B; rucaparib, nicotinamide and ML-9 inhibit smooth muscle contraction in PE-constricted rat aorta. Panel C; inhibition of arterial smooth muscle contraction by rucaparib is dependent on a mechanism in addition to MLCK inhibition. Constricted vessel segments were relaxed to the maximal degree achievable with ML-9, before being challenged with a relaxing cocktail of ML-9 plus rucaparib. The histograms illustrate the additive effects that...
Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endotheli...
Vascular tone is modulated by hormonal, neural and paracrine input for the proper regulation of bloo...
In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to b...
<div><p>Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplemen...
<p>Panel A; broad-spectrum antagonism of P2 receptors using suramin (inverted open triangles) abroga...
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the po...
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to sup-plement the p...
<p>Panels A and B; blockade of specific P2 receptor subtypes P2X<sub>4</sub>, P2X<sub>7</sub> and P2...
Regulation of smooth muscle contraction is driven by a number of protein kinases: the evidence for t...
Regulation of smooth muscle contraction is driven by a number of protein kinases: the evidence for t...
<p><sup>a</sup>Data presented represents the magnitude of vessel relaxation in response to the top c...
Mechanosensitive nonselective cation channels (NSC(ms)), protein kinase C (PKC), and Rho kinase (ROC...
Vascular resistance is mainly determined by the contraction of vascular smooth muscle (VSM), which i...
The final version of record is available at http://www.biochemj.org/bj/toc.htmThe signal transductio...
In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to b...
Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endotheli...
Vascular tone is modulated by hormonal, neural and paracrine input for the proper regulation of bloo...
In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to b...
<div><p>Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplemen...
<p>Panel A; broad-spectrum antagonism of P2 receptors using suramin (inverted open triangles) abroga...
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the po...
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to sup-plement the p...
<p>Panels A and B; blockade of specific P2 receptor subtypes P2X<sub>4</sub>, P2X<sub>7</sub> and P2...
Regulation of smooth muscle contraction is driven by a number of protein kinases: the evidence for t...
Regulation of smooth muscle contraction is driven by a number of protein kinases: the evidence for t...
<p><sup>a</sup>Data presented represents the magnitude of vessel relaxation in response to the top c...
Mechanosensitive nonselective cation channels (NSC(ms)), protein kinase C (PKC), and Rho kinase (ROC...
Vascular resistance is mainly determined by the contraction of vascular smooth muscle (VSM), which i...
The final version of record is available at http://www.biochemj.org/bj/toc.htmThe signal transductio...
In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to b...
Rho kinase is involved in the pathogenesis of hypertension, which favors the occurrence of endotheli...
Vascular tone is modulated by hormonal, neural and paracrine input for the proper regulation of bloo...
In addition to its role in the regulation of artery contraction, Rho kinase (ROCK) was reported to b...