Comparison of <i>C</i>. <i>albicans</i> proliferation-defective transcription factor mutants.

<p>(A). Heat map representation of gene expression ratios for 148 environmentally responsive genes at 24 hr postinfection (<i>rim101Δ/Δ</i>, <i>rob1Δ/Δ</i>, <i>rpn4Δ/Δ</i>, <i>sut1Δ/Δ</i>, or <i>zap1Δ/Δ</i>, each relative to the wild type) or 48 hr postinfection (<i>efg1Δ/Δ</i>, relative to the wild type). Complete data are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s005" target="_blank">S5 Data</a>. (B). Yield of <i>C</i>. <i>albicans</i> RNA relative to total kidney RNA for each mutant and complemented strain at 24 hr postinfection. Asterisks mark significant differences (<i>p</i>-value < 0.05) between mutants and respective complemented strains. (C). Histopathology images of kidney sections. All samples were at 24 hr postinfection. Arrows indicate fungal cells. The scale bar corresponds to 50 microns. For panel A, the specific strains used and the dose of viable cells per mouse, as determined by plating the inocula, were: CW 696 (wild type) 8.4 × 10⁵; CW730 (<i>rob1</i>) 10.2 × 10⁵; DAY25 (<i>rim101</i>) 11.1 × 10⁵; CW1018 (<i>efg1</i>) 9 × 10⁵; CW792 (<i>rpn4</i>) 7.9 × 10⁵; CW756 (<i>zap1</i>) 8.8 × 10⁵; CW704 (<i>sut1</i>) 8.6 × 10⁵. All numerical data for this figure are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s007" target="_blank">S7 Data</a>.