Antipsychotics treatment except clozapine commonly induce three IEGs, <i>c-fos</i>, <i>Arc</i> and <i>Egr2</i> in a dose-dependent manner in nucleus accumbens and striatum.

<p>(a) Dose-dependent effects of haloperidol (1 hr treatment, 0.03 mg/kg to 1 mg/kg, p.o.). Note that four IEGs (<i>c-fos</i>, <i>Arc</i>, <i>Egr1</i> and <i>Egr2</i>) are dose-dependently elevated in nucleus accumbens and striatum. The dashed horizontal line indicates baseline (the value of 1).Data are shown as mean± SEM (n = 4~5). *p<0.025, significantly different from vehicle at a dose of 0 mg/kg in Williams’ test. (b) TFPs of seven IEGs showing dose-response pattern by treatment of four antipsychotics in mouse brain. Significant induction for three IEGs (<i>c-fos</i>, <i>Arc</i> and <i>Egr2</i>) were commonly observed in nucleus accumbens and striatum among three antipsychotics, haloperidol, aripiprazole and olanzapine. Antipsychotics; haloperidol (1 hr treatment, 0.03 mg/kg to 1 mg/kg, p.o.), aripiprazole (2 hrs treatment, 0.1 mg/kg to 3 mg/kg, p.o.), olanzapine (1 hr treatment, 0.3 mg/kg to 10 mg/kg, p.o.) and clozapine (1 hr treatment, 1 mg/kg to 30 mg/kg, p.o.). The bar depicted in the bottom right corner represents the expression level of the gene searched in a TFP. Red represents high expression, green represents vehicle-control level expression, and blue represents low expression.