Thioredoxin reductase activity in auranofin treated Brugia spp.
- Christina A. Bulman (694015)
- Chelsea M. Bidlow (694016)
- Sara Lustigman (123305)
- Fidelis Cho-Ngwa (191165)
- David Williams (229939)
- Alberto A. Rascón, Jr (694017)
- Nancy Tricoche (322694)
- Moses Samje (191176)
- Aaron Bell (694018)
- Brian Suzuki (239548)
- K. C. Lim (140336)
- Nonglak Supakorndej (694019)
- Prasit Supakorndej (694020)
- Alan R. Wolfe (694021)
- Giselle M. Knudsen (217467)
- Steven Chen (145741)
- Chris Wilson (694022)
- Kean-Hooi Ang (694023)
- Michelle Arkin (694024)
- Jiri Gut (145726)
- Chris Franklin (694025)
- Chris Marcellino (186241)
- James H. McKerrow (113918)
- Anjan Debnath (352163)
- Judy A. Sakanari (694026)
Publication date
February 2015
DOIAbstract
<p>(A) Activity of endogenous <i>Brugia</i> thioredoxin reductase from soluble worm lysates following incubation with 1% DMSO or 0.3 μM, 0.1 μM, or 0.03 μM of auranofin <i>in vitro</i>. Percentages indicate the percent activity of TrxR compared to DMSO controls. (B) Enzymatic activity of worms collected 16 days after the last dose from gerbils treated with auranofin or vehicle. The lysate of worms taken from gerbils treated with auranofin shows 49% less thioredoxin reductase activity than those taken from gerbils treated with vehicle only. Percentages indicate the percent activity of TrxR compared to vehicle controls.</p
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