Human S100A9 induced THP-1 cell migration requires MEK/ERK and PI3K but not p38.

<p>Chemotactic response of THP-1 towards hS100A9 (1 ng/ml) in the absence or presence of specific inhibitors targeting the MEK/ERK pathway (A), the PI3 kinase pathway (B), the NF-κB pathway (C), and the p38 MAPK pathway (D). The inhibitor concentrations (μM) are indicated. Data shown is mean±SD of triplicate samples from a representative of three independent experiments.