Porphyrins as the early biomarkers for arsenic exposure of human

To investigate the effects of arsenic exposure on porphyrins excretion profiles in human, porphyrins were measured by HPLC and total arsenic by HG-AAS in urine samples collected from arsenicosis-endemic areas and control sites in Guizhou Province. Analytical data showed that urinary uroporphyrin-III and coproporphyrin-III were significantly elevated in arsenic-exposed group compared with those in control group, while urinary coproporphyrin-I was not significantly higher in arsenic-exposed group than that in control group. Not any significant difference was found in porphyrins between the male and female except for 20-40 years age group. As far as age was concerned, arsenic-exposed group o